ABSTRACT The manufacturing process for biological products is complex, expensive and critical to the final product, with an impact on their efficacy and safety.They have been increasingly used to treat several diseases, and account for approximately 50% of the yearly budget for the Brazilian public health system.As the patents of biological product
This paper provides a survey of the state of the art in terminologies and ontologies applied to Biology and Medicine.Not intending to be fully comprehensive, we describe some of the most relevant resources that currently attract interest from industry and academia.We introduce a description framework and compare the systems in terms of their archit
In the 2000s, the idea of a so-called middle-segment arose in North-West Europe to address the criticism on intensive broiler production systems.Middle-segment systems being indoor housing of slower-growing broiler strains at a stocking density ≤38 kg/m2.Previous literature showed that Dutch middle-segment systems entail a relatively large ga
Fes1 is a conserved armadillo repeat-containing Hsp70 nucleotide exchange factor important for growth at high temperature, proteasomal protein degradation and prion propagation.Depleting or mutating Fes1 induces a stress response and causes defects in these processes that are ascribed solely to disruption of Fes1 regulation of Hsp70.Here, we find F